CELSR2

Across TCGA patient cohorts, CELSR2 mutation is significantly associated with the total protein of many other genes, with 99 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CELSR2-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and 4E-BP1. Each is linked with CELSR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CELSR2-to-partner and partner-to-CELSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CELSR2-low versus CELSR2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR2→partner) and Y-score (partner→CELSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.383	+2.824	<.001	.001	3	6
UCEC	eIF4E →	+0.160	+1.371	.001	<.001	3	4
STAD	4E-BP1 →	+0.266	+1.906	.014	.015	3	4
UCEC	Cyclin-B1 →	+0.447	+1.893	<.001	<.001	3	4
BLCA	AR →	-0.260	-3.000	.028	.034	3	3
STAD	GAPDH →	+0.306	+3.321	.014	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

Caspase-7-cleavedD198 by CELSR2 expression — COAD

Explore this box plot interactively →