CELSR2

Across TCGA cell cohorts, CELSR2 mutation is significantly associated with the RNA expression of many other genes, with 1,244 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CELSR2-associated genes across cancer lineages are LYG1, DESI1, and PXYLP1. Each is linked with CELSR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CELSR2-to-partner and partner-to-CELSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by CELSR2-low versus CELSR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR2→partner) and Y-score (partner→CELSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.877	+2.290	<.001	<.001	3	4
LARGE_INTESTINE	DESI1 →	+0.555	+2.700	<.001	<.001	3	3
BLOOD_Leukemia	PXYLP1 →	+1.265	+2.489	.001	.007	3	3
LARGE_INTESTINE	HSPA4L →	+1.000	+3.169	<.001	.006	3	3
LARGE_INTESTINE	ME2 →	+0.972	+2.222	<.001	.001	3	3
BLOOD_Leukemia	PNLDC1 →	+0.109	+2.727	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,244 associations by consensus.

LYG1 by CELSR2 expression — LARGE_INTESTINE

Explore this box plot interactively →