CELSR2

Across TCGA cell cohorts, CELSR2 mutation is significantly associated with the mutation status of many other genes, with 5,969 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CELSR2-associated genes across cancer lineages are COL7A1, CABIN1, and PCDHB7. Each is linked with CELSR2 in more than 6 cancer types. Because this analysis shows association rather than direction, both CELSR2-to-partner and partner-to-CELSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL7A1 grouped by CELSR2-low versus CELSR2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR2→partner) and Y-score (partner→CELSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	COL7A1 →	+4.029	+4.029	<.001	<.001	1	7
SKIN	CABIN1 →	+3.614	+3.614	<.001	<.001	1	7
BLOOD_Lymphoma	PCDHB7 →	+3.523	+3.232	.006	.006	1	7
SOFT_TISSUE	PLXNA1 →	+3.722	+4.022	.003	.003	1	7
OVARY	ZNF609 →	+4.688	+3.310	<.001	<.001	1	7
LARGE_INTESTINE	PI4KA →	+3.807	+2.292	<.001	<.001	1	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,969 associations by consensus.

COL7A1 by CELSR2 expression — PANCREAS

Explore this box plot interactively →