CELF3

Across TCGA patient cohorts, CELF3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CELF3-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and p70-S6K_pT389. Each is linked with CELF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CELF3-to-partner and partner-to-CELF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CELF3-low versus CELF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELF3→partner) and Y-score (partner→CELF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.176	+1.906	.015	.015	3	2
UCEC	mTOR_pS2448 →	-0.149	-1.736	.003	.007	3	2
UCEC	p70-S6K_pT389 →	-0.155	-2.584	.018	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.440	+1.827	.032	.015	3	2
UCEC	14-3-3_beta →	-0.072	-2.558	.040	.010	3	1
UCEC	EGFR_pY1068 →	-0.295	-2.459	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

eIF4E by CELF3 expression — UCEC

Explore this box plot interactively →