CELF3

Across TCGA cell cohorts, CELF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,866 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CELF3-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Protein sumoylation, and Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway. Each is linked with CELF3 in more than 6 cancer types. Because this analysis shows association rather than direction, both CELF3-to-partner and partner-to-CELF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by CELF3-low versus CELF3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CELF3→partner) and Y-score (partner→CELF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Transcription pausing by RNA polymerase II →	+0.091	+0.037	.003	.006	2	7
LUNG_SCLC	Protein sumoylation →	+0.079	+2.551	.007	.002	3	6
LUNG_SCLC	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.104	+2.800	<.001	<.001	3	6
LUNG_SCLC	External encapsulating structure organization →	-0.068	-2.967	.007	<.001	3	6
LUNG_SCLC	Receptor-mediated endocytosis of virus by host cell →	-0.201	-2.843	<.001	<.001	3	5
LUNG_SCLC	Stress granule assembly →	+0.092	+2.158	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,866 associations by consensus.

Transcription pausing by RNA polymerase II by CELF3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →