CELF1

Across TCGA patient cohorts, CELF1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CELF1-associated genes across cancer lineages are eIF4E, eIF4G, and Notch1. Each is linked with CELF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CELF1-to-partner and partner-to-CELF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CELF1-low versus CELF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELF1→partner) and Y-score (partner→CELF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+1.700	.047	.044	3	1
UCEC	eIF4G →	+0.260	+3.169	.048	.019	3	1
UCEC	Notch1 →	+0.206	+2.906	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.437	+2.222	.001	.011	3	1
UCEC	PCNA →	+0.320	+4.000	<.001	<.001	3	1
UCEC	PDCD4 →	-0.587	-2.449	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by CELF1 expression — UCEC

Explore this box plot interactively →