CELA3A

Across TCGA patient cohorts, CELA3A mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CELA3A-associated genes across cancer lineages are ATM, Bak, and 4E-BP1. Each is linked with CELA3A in more than 1 cancer types. Because this analysis shows association rather than direction, both CELA3A-to-partner and partner-to-CELA3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CELA3A-low versus CELA3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELA3A→partner) and Y-score (partner→CELA3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.649	-2.807	.001	.003	3	2
UCEC	Bak →	+0.224	+2.115	.040	.019	3	2
UCEC	4E-BP1 →	+0.256	+2.837	.030	.035	3	2
UCEC	HSP70 →	-0.489	-3.312	.005	.010	3	1
UCEC	JNK2 →	+0.275	+2.807	.001	.003	3	1
UCEC	Ku80 →	+0.222	+2.128	.031	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by CELA3A expression — UCEC

Explore this box plot interactively →