CELA1

Across TCGA patient cohorts, CELA1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CELA1-associated genes across cancer lineages are p21, Tuberin_pT1462, and ASNS. Each is linked with CELA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CELA1-to-partner and partner-to-CELA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by CELA1-low versus CELA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELA1→partner) and Y-score (partner→CELA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.238	+2.321	.013	.035	3	1
UCEC	Tuberin_pT1462 →	+0.233	+3.009	.045	.019	3	1
UCEC	ASNS →	+0.602	+3.459	<.001	.005	3	1
UCEC	Tuberin →	+0.386	+2.331	.004	.019	2	1
UCEC	MEK1 →	+0.614	+3.459	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p21 by CELA1 expression — UCEC

Explore this box plot interactively →