CELA1

Across TCGA cell cohorts, CELA1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CELA1-associated genes across cancer lineages are TMEM207, NMRK2, and AFM. Each is linked with CELA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CELA1-to-partner and partner-to-CELA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM207 grouped by CELA1-low versus CELA1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELA1→partner) and Y-score (partner→CELA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM207 →	+0.168	+4.672	<.001	.002	3	1
BREAST	NMRK2 →	+0.052	+4.199	<.001	.007	3	1
BREAST	AFM →	+0.052	+4.199	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.080	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	OR5AK2 →	+0.034	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.239	+3.103	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TMEM207 by CELA1 expression — BREAST

Explore this box plot interactively →