Across TCGA pan-cancer cohorts, CEACAMP3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CEACAMP3’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CEACAMP3 RNA is repressed in tumor relative to normal tissue. In most cancer types CEACAMP3 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.
LUSC and COAD are the cancer types where CEACAMP3 tumor–normal differential expression is most reproducible.