CEACAM8

Across TCGA patient cohorts, CEACAM8 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEACAM8-associated genes across cancer lineages are Notch1, BRD4, and IRS1. Each is linked with CEACAM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEACAM8-to-partner and partner-to-CEACAM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CEACAM8-low versus CEACAM8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM8→partner) and Y-score (partner→CEACAM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.258	+3.700	<.001	.001	2	3
UCEC	BRD4 →	+0.288	+2.999	.020	.034	3	2
SKCM	IRS1 →	+0.174	+2.824	.018	.034	3	2
UCEC	eIF4E →	+0.198	+2.584	.044	.011	3	1
UCEC	JNK2 →	+0.362	+2.486	<.001	.009	3	1
UCEC	Ku80 →	+0.303	+2.331	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Notch1 by CEACAM8 expression — UCEC

Explore this box plot interactively →