CEACAM8

Across TCGA cell cohorts, CEACAM8 RNA expression is significantly associated with the go_rna of many other GO terms, with 363 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEACAM8-associated GO terms across cancer lineages are Extrinsic apoptotic signaling pathway in absence of ligand, Extracellular exosome biogenesis, and Fatty acid metabolic process. Each is linked with CEACAM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEACAM8-to-partner and partner-to-CEACAM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Extrinsic apoptotic signaling pathway in absence of ligand grouped by CEACAM8-low versus CEACAM8-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM8→partner) and Y-score (partner→CEACAM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Extrinsic apoptotic signaling pathway in absence of ligand →	+0.058	+0.008	.009	.003	3	3
LUNG_NSCLC_LUAD	Extracellular exosome biogenesis →	+0.172	+0.014	<.001	.007	3	3
LARGE_INTESTINE	Fatty acid metabolic process →	+0.050	+0.110	<.001	.004	3	3
CNS	Regulation of myotube differentiation →	+0.071	+0.001	.007	.005	3	3
CNS	T cell selection →	+0.113	+0.002	<.001	.008	3	2
LUNG_NSCLC_LUAD	Regulation of Golgi inheritance →	+0.075	+0.009	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

Extrinsic apoptotic signaling pathway in absence of ligand by CEACAM8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →