CEACAM5

Across TCGA pan-cancer cohorts, CEACAM5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CEACAM5 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CEACAM5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CEACAM5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where CEACAM5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.952	0.847	.026	8	view →
PDAC	DFS	Tertile	IV	0.217	0.749	.024	6	view →
LUAD	DFS	Tertile	All	0.868	0.959	.039	2	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CEACAM5–UCEC (DFS)

Open the UCEC breakdown →