CEACAM5

Across TCGA patient cohorts, CEACAM5 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEACAM5-associated genes across cancer lineages are PKC-b-II_pS660, NDRG1_pT346, and FoxM1. Each is linked with CEACAM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEACAM5-to-partner and partner-to-CEACAM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by CEACAM5-low versus CEACAM5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM5→partner) and Y-score (partner→CEACAM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-b-II_pS660 →	-0.279	-2.459	.012	.017	3	3
SKCM	NDRG1_pT346 →	-0.609	-2.087	.015	.005	3	2
UCEC	FoxM1 →	+0.181	+1.321	.036	.029	3	2
UCEC	GSK-3_pS9 →	-0.280	-1.415	.038	.043	3	2
UCEC	JNK_pT183_Y185 →	-0.160	-1.807	.004	.024	3	2
UCEC	MAPK_pT202_Y204 →	-0.497	-3.687	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PKC-b-II_pS660 by CEACAM5 expression — SKCM

Explore this box plot interactively →