CEACAM4

Across TCGA patient cohorts, CEACAM4 mutation is significantly associated with the RNA expression of many other genes, with 1,261 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEACAM4-associated genes across cancer lineages are OR9Q2, FCRL4, and GHITM. Each is linked with CEACAM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEACAM4-to-partner and partner-to-CEACAM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9Q2 grouped by CEACAM4-low versus CEACAM4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM4→partner) and Y-score (partner→CEACAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR9Q2 →	+0.024	+5.000	<.001	.003	3	3
UCEC	FCRL4 →	+0.094	+2.511	.008	.003	3	2
UCEC	GHITM →	+0.626	+3.513	.001	.002	3	2
UCEC	DAPK3 →	+0.473	+2.354	.003	.003	3	2
UCEC	CHAF1A →	+0.779	+3.021	<.001	<.001	3	2
UCEC	STIP1 →	+0.462	+2.609	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,261 associations by consensus.

OR9Q2 by CEACAM4 expression — LUAD

Explore this box plot interactively →