CEACAM4

Across TCGA patient cohorts, CEACAM4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEACAM4-associated genes across cancer lineages are p62 Lck ligand, ATM, and 14-3-3_beta. Each is linked with CEACAM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEACAM4-to-partner and partner-to-CEACAM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CEACAM4-low versus CEACAM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM4→partner) and Y-score (partner→CEACAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.429	+3.331	.003	.005	2	4
UCEC	ATM →	-0.519	-2.000	.011	.032	3	2
UCEC	14-3-3_beta →	-0.132	-3.295	.003	.009	3	1
UCEC	EGFR_pY1068 →	-0.244	-2.321	.031	.033	3	1
UCEC	P-Cadherin →	-0.174	-2.321	.007	.033	3	1
UCEC	Annexin-1 →	+0.732	+2.700	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

p62 Lck ligand by CEACAM4 expression — UCEC

Explore this box plot interactively →