CEACAM4

Across TCGA cell cohorts, CEACAM4 mutation is significantly associated with the mutation status of many other genes, with 5,209 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEACAM4-associated genes across cancer lineages are TRPV4, POU2F1, and EEF2K. Each is linked with CEACAM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEACAM4-to-partner and partner-to-CEACAM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPV4 grouped by CEACAM4-low versus CEACAM4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM4→partner) and Y-score (partner→CEACAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRPV4 →	+4.239	+5.053	.007	.007	1	3
BLOOD_Leukemia	POU2F1 →	+6.050	+4.975	<.001	<.001	1	3
LARGE_INTESTINE	EEF2K →	+3.951	+4.321	<.001	<.001	1	3
BLOOD_Leukemia	PANX2 →	+3.243	+3.762	.001	.001	1	3
BLOOD_Leukemia	ANO8 →	+3.050	+4.169	<.001	<.001	1	3
LARGE_INTESTINE	CDH3 →	+2.407	+2.886	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,209 associations by consensus.

TRPV4 by CEACAM4 expression — SKIN

Explore this box plot interactively →