CEACAM3

Across TCGA patient cohorts, CEACAM3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEACAM3-associated genes across cancer lineages are RAD51, Syk, and IGFBP2. Each is linked with CEACAM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEACAM3-to-partner and partner-to-CEACAM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by CEACAM3-low versus CEACAM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM3→partner) and Y-score (partner→CEACAM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.154	+3.000	.017	.036	3	2
UCEC	Syk →	-0.394	-2.986	.024	.035	3	2
UCEC	IGFBP2 →	-1.097	-3.169	<.001	.018	3	1
UCEC	Ku80 →	+0.269	+1.887	.014	.031	3	1
UCEC	MEK1 →	+0.596	+3.584	<.001	.002	3	1
UCEC	Notch1 →	+0.276	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RAD51 by CEACAM3 expression — UCEC

Explore this box plot interactively →