CDYL2

Across TCGA patient cohorts, CDYL2 mutation is significantly associated with the RNA expression of many other genes, with 5,707 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDYL2-associated genes across cancer lineages are PBK, RAD23A, and PNP. Each is linked with CDYL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDYL2-to-partner and partner-to-CDYL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by CDYL2-low versus CDYL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDYL2→partner) and Y-score (partner→CDYL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+1.075	+2.711	<.001	<.001	3	3
UCEC	RAD23A →	+0.391	+2.021	.004	<.001	3	3
UCEC	PNP →	+0.523	+2.032	.002	<.001	3	3
UCEC	GAPDHP72 →	+0.423	+3.040	<.001	<.001	3	3
UCEC	EIF4A1P10 →	+0.621	+2.949	<.001	<.001	3	3
UCEC	CCNB2 →	+0.850	+2.700	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,707 associations by consensus.

PBK by CDYL2 expression — UCEC

Explore this box plot interactively →