CDX2

Across TCGA patient cohorts, CDX2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDX2-associated genes across cancer lineages are p70-S6K, Src_pY527, and GAPDH. Each is linked with CDX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDX2-to-partner and partner-to-CDX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by CDX2-low versus CDX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX2→partner) and Y-score (partner→CDX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.199	+1.901	.026	.031	3	2
UCEC	Src_pY527 →	-0.397	-2.990	.047	.036	3	2
UCEC	GAPDH →	+0.542	+3.169	.030	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.217	-2.571	.005	.011	3	1
UCEC	Ku80 →	+0.342	+2.598	.001	.006	3	1
UCEC	PCNA →	+0.248	+2.321	.013	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

p70-S6K by CDX2 expression — UCEC

Explore this box plot interactively →