CDX2

Across TCGA cell cohorts, CDX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,695 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDX2-associated GO terms across cancer lineages are Regulation of smooth muscle cell-matrix adhesion, Alcohol biosynthetic process, and Sugar mediated signaling pathway. Each is linked with CDX2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDX2-to-partner and partner-to-CDX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of smooth muscle cell-matrix adhesion grouped by CDX2-low versus CDX2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX2→partner) and Y-score (partner→CDX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of smooth muscle cell-matrix adhesion →	-1.067	-2.239	.004	.002	3	6
LARGE_INTESTINE	Alcohol biosynthetic process →	+0.049	+2.540	<.001	<.001	3	6
LUNG_NSCLC_LUAD	Sugar mediated signaling pathway →	-0.133	-1.372	.001	.001	3	5
LUNG_NSCLC_LUAD	Glucose mediated signaling pathway →	-0.133	-1.372	.001	.001	3	5
LUNG_NSCLC_LUAD	Hexose mediated signaling →	-0.133	-1.372	.001	.001	3	5
STOMACH	Receptor-mediated endocytosis of virus by host cell →	-0.169	-2.065	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,695 associations by consensus.

Regulation of smooth muscle cell-matrix adhesion by CDX2 expression — STOMACH

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