CDX1

Across TCGA patient cohorts, CDX1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDX1-associated genes across cancer lineages are MEK1, AMPK_alpha, and Tuberin. Each is linked with CDX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDX1-to-partner and partner-to-CDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CDX1-low versus CDX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX1→partner) and Y-score (partner→CDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.476	+3.000	.024	.037	3	1
UCEC	AMPK_alpha →	-0.246	-3.000	.025	.037	3	1
UCEC	Tuberin →	+0.324	+3.000	.037	.037	3	1
UCEC	c-Met_pY1235 →	+0.088	+3.009	.040	.019	3	1
UCEC	Cyclin-E2 →	+0.232	+2.817	.017	.036	3	1
UCEC	Ku80 →	+0.272	+3.013	.046	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by CDX1 expression — UCEC

Explore this box plot interactively →