CDX1

Across TCGA cell cohorts, CDX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,095 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDX1-associated GO terms across cancer lineages are Negative regulation of translational initiation, Regulation of osteoblast proliferation, and Immunoglobulin mediated immune response. Each is linked with CDX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDX1-to-partner and partner-to-CDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of translational initiation grouped by CDX1-low versus CDX1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX1→partner) and Y-score (partner→CDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of translational initiation →	+0.071	+0.046	.003	.001	3	4
LARGE_INTESTINE	Regulation of osteoblast proliferation →	-0.103	-2.797	<.001	<.001	3	4
BLOOD_Leukemia	Immunoglobulin mediated immune response →	-0.059	-0.053	.001	.006	3	3
BLOOD_Leukemia	Monosaccharide metabolic process →	+0.035	+0.025	.002	<.001	3	3
BLOOD_Leukemia	Zinc ion import across plasma membrane →	+0.090	+0.031	<.001	.005	3	3
LARGE_INTESTINE	Lactation →	+0.126	+3.384	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,095 associations by consensus.

Negative regulation of translational initiation by CDX1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →