CDX1

Across TCGA cell cohorts, CDX1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDX1-associated genes across cancer lineages are MS4A10, IL17F, and CARD18. Each is linked with CDX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDX1-to-partner and partner-to-CDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A10 grouped by CDX1-low versus CDX1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX1→partner) and Y-score (partner→CDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
LARGE_INTESTINE	IL17F →	+0.050	+3.766	.002	.004	3	1
LARGE_INTESTINE	CARD18 →	+0.261	+3.347	.003	.005	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WNT8A →	+0.018	+3.632	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MS4A10 by CDX1 expression — OVARY

Explore this box plot interactively →