CDV3

Across TCGA patient cohorts, CDV3 mutation is significantly associated with the RNA expression of many other genes, with 3,396 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDV3-associated genes across cancer lineages are HMGB3P26, NCOA4P1, and ZNF234. Each is linked with CDV3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDV3-to-partner and partner-to-CDV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB3P26 grouped by CDV3-low versus CDV3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDV3→partner) and Y-score (partner→CDV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HMGB3P26 →	+0.066	+5.103	<.001	.008	3	2
UCEC	NCOA4P1 →	+0.069	+1.709	<.001	.007	3	2
UCEC	ZNF234 →	+0.435	+1.786	.001	.008	3	1
UCEC	ROCK1P1 →	+0.491	+2.436	<.001	.001	3	1
UCEC	RN7SL134P →	+0.111	+2.184	.001	.004	3	1
UCEC	MIR4701 →	+0.589	+1.752	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,396 associations by consensus.

HMGB3P26 by CDV3 expression — CESC

Explore this box plot interactively →