CDT1

Across TCGA patient cohorts, CDT1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDT1-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and Rad50. Each is linked with CDT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDT1-to-partner and partner-to-CDT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CDT1-low versus CDT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDT1→partner) and Y-score (partner→CDT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.191	+3.013	.033	.018	3	3
UCEC	Caspase-7-cleavedD198 →	+0.761	+3.341	.002	.005	3	3
UCEC	Rad50 →	-0.213	-1.700	.038	.044	3	2
UCEC	A-Raf_pS299 →	-0.211	-3.584	<.001	.002	3	1
UCEC	ERK2 →	+0.227	+3.321	.005	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.164	-2.212	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by CDT1 expression — UCEC

Explore this box plot interactively →