Across TCGA pan-cancer cohorts, CDSN mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated CDSN data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDSN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CDSN expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC are the cancer types where CDSN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.919	0.604	.015	20	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: CDSN tumor-vs-normal RNA expression · all CDSN data types