Across TCGA patient cohorts, CDSN mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CDSN-associated genes across cancer lineages are JNK2, MEK1, and Shc_pY317. Each is linked with CDSN in more than 1 cancer types. Because this analysis shows association rather than direction, both CDSN-to-partner and partner-to-CDSN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDSN→partner) and Y-score (partner→CDSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.327	+3.026	.001	.018	3	1
UCEC	MEK1 →	+0.421	+3.169	.028	.019	3	1
UCEC	Shc_pY317 →	-0.207	-3.000	.009	.036	3	1
UCEC	ATM →	-0.693	-3.321	.003	.010	3	1
UCEC	Caspase-8 →	-0.272	-3.321	.039	.010	3	1
SKCM	HSP70 →	-0.474	-3.000	.028	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

CDSN survival (RNA) · tumor vs normal (RNA) · all CDSN data types