CDON

Across TCGA patient cohorts, CDON mutation is significantly associated with the RNA expression of many other genes, with 3,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDON-associated genes across cancer lineages are HELLS, DTL, and MED8. Each is linked with CDON in more than 3 cancer types. Because this analysis shows association rather than direction, both CDON-to-partner and partner-to-CDON results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELLS grouped by CDON-low versus CDON-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDON→partner) and Y-score (partner→CDON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HELLS →	+0.471	+1.916	.004	.009	3	4
SKCM	DTL →	+0.572	+2.816	.005	.001	3	4
COAD	MED8 →	+0.237	+3.387	.007	.004	3	4
COAD	SFXN1 →	+0.459	+3.499	<.001	.002	3	4
UCEC	TIPIN →	+0.452	+1.947	<.001	<.001	3	4
UCEC	WRAP53 →	+0.345	+2.123	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,714 associations by consensus.

HELLS by CDON expression — SKCM

Explore this box plot interactively →