Across TCGA pan-cancer cohorts, CDNF mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CDNF data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CDNF mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CDNF expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where CDNF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.941	0.686	<.001	46	view →
CCRCC	DFS	Tertile	All	0.899	0.614	.034	5	view →
LUAD	DFS	Tertile	All	0.729	1.000	.033	2	view →
HNSC	DFS	Median	III,IV	0.723	0.522	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: CDNF tumor-vs-normal RNA expression · all CDNF data types