CDKN3

Across TCGA pan-cancer cohorts, CDKN3 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CDKN3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CDKN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDKN3 is over-expressed in tumor.

HNSC, BLCA, and KIRP are the cancer types where CDKN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDKN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.970	<.001	12	view →
BLCA	Male	All	+2.420	<.001	11	view →
KIRP	All	III,IV	+2.253	<.001	11	view →
KIRC	Male	IV	+1.389	<.001	11	view →
LUSC	Female	II,III,IV	+3.834	<.001	9	view →
STAD	Female	All	+2.889	<.001	9	view →
LIHC	Male	All	+2.772	<.001	9	view →
LUAD	Male	III,IV	+2.616	<.001	9	view →
UCEC	All	II,III,IV	+3.303	<.001	8	view →
COAD	Female	II,III,IV	+1.465	<.001	8	view →
READ	All	All	+1.086	.001	7	view →
BRCA	All	II,III,IV	+2.308	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CDKN3–HNSC

Open the HNSC breakdown →