CDKN2C

Across TCGA pan-cancer cohorts, CDKN2C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CDKN2C data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CDKN2C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CDKN2C expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where CDKN2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	II,III,IV	0.368	1.000	.014	24	view →
LUAD	OS	Median	All	1.000	0.764	.004	23	view →
CCRCC	OS	Median	All	0.909	1.000	.019	11	view →
PDAC	OS	Quartile	All	0.655	0.426	.006	10	view →
LSCC	DFS	Median	II,III,IV	0.561	0.837	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CDKN2C–UCEC (OS)

Open the UCEC breakdown →