CDKN2C

Across TCGA pan-cancer cohorts, CDKN2C mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CDKN2C’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CDKN2C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CDKN2C is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where CDKN2C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDKN2C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+0.729	<.001	12	view →
HNSC	All	III,IV	−0.636	<.001	11	view →
COAD	Male	III,IV	−0.771	<.001	10	view →
LUAD	Female	III,IV	−0.878	<.001	9	view →
LSCC	Male	III,IV	−0.780	<.001	8	view →
PDAC	Male	II,III,IV	+0.613	.008	4	view →
OV	All	All	−1.107	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CDKN2C–CCRCC

Open the CCRCC breakdown →