CDKN2C

Across TCGA patient cohorts, CDKN2C mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN2C-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and eIF4E. Each is linked with CDKN2C in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN2C-to-partner and partner-to-CDKN2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CDKN2C-low versus CDKN2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN2C→partner) and Y-score (partner→CDKN2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.482	+3.000	.011	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.631	+3.019	.042	.019	3	1
UCEC	eIF4E →	+0.309	+3.169	.005	.019	2	1
UCEC	4E-BP1 →	+0.512	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MEK1 by CDKN2C expression — UCEC

Explore this box plot interactively →