CDKN2B

Across TCGA cell cohorts, CDKN2B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,936 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CDKN2B-associated GO terms across cancer lineages are Negative regulation of immature T cell proliferation, Negative regulation of immature T cell proliferation in thymus, and Regulation of macrophage apoptotic process. Each is linked with CDKN2B in more than 12 cancer types. Because this analysis shows association rather than direction, both CDKN2B-to-partner and partner-to-CDKN2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of immature T cell proliferation grouped by CDKN2B-low versus CDKN2B-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN2B→partner) and Y-score (partner→CDKN2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of immature T cell proliferation →	+1.380	+3.407	<.001	<.001	3	13
KIDNEY	Negative regulation of immature T cell proliferation in thymus →	+1.247	+2.140	<.001	<.001	3	13
SOFT_TISSUE	Regulation of macrophage apoptotic process →	+0.190	+2.024	<.001	<.001	3	12
BREAST	Negative regulation of B cell proliferation →	+0.241	+2.095	.003	<.001	3	12
OESOPHAGUS	Positive regulation of macrophage apoptotic process →	+1.026	+2.708	.001	<.001	2	12
STOMACH	Cellular response to cell-matrix adhesion →	-0.246	-2.071	.002	.005	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,936 associations by consensus.

Negative regulation of immature T cell proliferation by CDKN2B expression — URINARY_TRACT

Explore this box plot interactively →