CDKN2B-AS1

Across TCGA pan-cancer cohorts, CDKN2B-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CDKN2B-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CDKN2B-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDKN2B-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and SKCM show a favorable association.

ACC, UVM, and MESO are the cancer types where CDKN2B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.367	0.701	<.001	98	view →
UVM	DFS	Tertile	II,III,IV	0.305	0.767	<.001	96	view →
MESO	OS	Median	II,III,IV	0.674	0.444	<.001	75	view →
LIHC	DFS	Median	All	0.464	0.618	<.001	58	view →
KICH	DFS	Quartile	All	0.639	1.000	.002	50	view →
UCEC	DFS	Tertile	All	0.528	0.784	<.001	50	view →
KIRC	DFS	Tertile	All	0.449	0.695	<.001	29	view →
SKCM	OS	Median	III,IV	0.864	0.731	.006	26	view →
CESC	OS	Median	All	0.859	0.730	.004	20	view →
PRAD	DFS	Median	All	0.843	0.919	.006	14	view →
COAD	DFS	Quartile	II,III,IV	0.553	0.373	.016	13	view →
LUAD	DFS	Tertile	III,IV	0.366	0.560	.026	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CDKN2B-AS1–ACC (DFS)

Open the ACC breakdown →