CDKN2AIP

Across TCGA patient cohorts, CDKN2AIP mutation is significantly associated with the RNA expression of many other genes, with 767 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN2AIP-associated genes across cancer lineages are ZYXP1, MIR1224, and RN7SKP12. Each is linked with CDKN2AIP in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN2AIP-to-partner and partner-to-CDKN2AIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZYXP1 grouped by CDKN2AIP-low versus CDKN2AIP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN2AIP→partner) and Y-score (partner→CDKN2AIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZYXP1 →	+0.248	+8.471	<.001	.005	3	2
UCEC	MIR1224 →	+0.339	+2.703	<.001	.001	3	2
UCEC	RN7SKP12 →	+0.181	+2.744	<.001	.004	3	2
COAD	MTND3P13 →	+0.128	+4.308	<.001	.009	3	2
BRCA	MIR3648-1 →	+0.534	+9.057	<.001	.003	3	1
SKCM	RNU6-1057P →	+0.392	+5.037	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 767 associations by consensus.

ZYXP1 by CDKN2AIP expression — BRCA

Explore this box plot interactively →