CDKN2AIP

Across TCGA patient cohorts, CDKN2AIP mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN2AIP-associated genes across cancer lineages are EGFR_pY1068, ACC_pS79, and Acetyl-a-Tubulin-Lys40. Each is linked with CDKN2AIP in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN2AIP-to-partner and partner-to-CDKN2AIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CDKN2AIP-low versus CDKN2AIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN2AIP→partner) and Y-score (partner→CDKN2AIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.219	-2.115	.046	.019	3	1
UCEC	ACC_pS79 →	+0.306	+2.999	.043	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.597	+2.115	.007	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.185	-3.459	.011	.005	3	1
UCEC	MSH2 →	-0.205	-2.973	.042	.035	3	1
UCEC	p27_pT198 →	+0.145	+3.906	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by CDKN2AIP expression — UCEC

Explore this box plot interactively →