CDKL5

Across TCGA patient cohorts, CDKL5 protein abundance is significantly associated with the RNA expression of many other genes, with 10,033 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDKL5-associated genes across cancer lineages are PPFIA2, SLC6A1, and MYL3. Each is linked with CDKL5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDKL5-to-partner and partner-to-CDKL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDKL5 versus PPFIA2 in GBM, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL5→partner) and Y-score (partner→CDKL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPFIA2 →	+1.322	+0.463	<.001	.002	3	4
GBM	SLC6A1 →	+1.067	+0.592	<.001	<.001	3	4
BRCA	MYL3 →	+0.344	+0.274	.008	.006	3	4
LUAD	CYS1 →	+1.088	+0.399	<.001	<.001	3	4
LUAD	DIO3OS →	+0.586	+0.305	<.001	<.001	3	4
LSCC	GJA6P →	+0.524	+0.359	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,033 associations by consensus.

CDKL5 vs PPFIA2 — GBM

Explore this scatter interactively →