CDKL5

Across TCGA cell cohorts, CDKL5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,908 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CDKL5-associated GO terms across cancer lineages are Golgi vesicle transport, Macroautophagy, and Autophagosome organization. Each is linked with CDKL5 in more than 15 cancer types. Because this analysis shows association rather than direction, both CDKL5-to-partner and partner-to-CDKL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi vesicle transport grouped by CDKL5-low versus CDKL5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL5→partner) and Y-score (partner→CDKL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Golgi vesicle transport →	+0.083	+0.786	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.064	+0.754	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Autophagosome organization →	+0.049	+0.559	.002	.007	3	15
OESOPHAGUS	Cytosolic transport →	+0.074	+0.775	.001	<.001	3	14
OESOPHAGUS	Post-Golgi vesicle-mediated transport →	+0.085	+0.565	<.001	.002	3	14
SOFT_TISSUE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.073	+0.901	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,908 associations by consensus.

Golgi vesicle transport by CDKL5 expression — OESOPHAGUS

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