CDKL5

Across TCGA cell cohorts, CDKL5 mutation is significantly associated with the RNA expression of many other genes, with 170 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDKL5-associated genes across cancer lineages are B4GALNT2, IQCF5, and RBP2. Each is linked with CDKL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKL5-to-partner and partner-to-CDKL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B4GALNT2 grouped by CDKL5-low versus CDKL5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL5→partner) and Y-score (partner→CDKL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	B4GALNT2 →	+0.029	+5.066	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	1
BLOOD_Leukemia	RBP2 →	+0.054	+4.359	<.001	<.001	3	1
BLOOD_Leukemia	MYOD1 →	+0.012	+3.922	<.001	.002	3	1
BLOOD_Leukemia	LRRC9 →	+0.168	+4.007	.006	.002	3	1
BLOOD_Leukemia	FLG2 →	+0.110	+4.007	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 170 associations by consensus.

B4GALNT2 by CDKL5 expression — BLOOD_Leukemia

Explore this box plot interactively →