CDKL5

Across TCGA cell cohorts, CDKL5 mutation is significantly associated with the mutation status of many other genes, with 5,259 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDKL5-associated genes across cancer lineages are CNTN4, ASTN2, and DSP. Each is linked with CDKL5 in more than 6 cancer types. Because this analysis shows association rather than direction, both CDKL5-to-partner and partner-to-CDKL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNTN4 grouped by CDKL5-low versus CDKL5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL5→partner) and Y-score (partner→CDKL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CNTN4 →	+5.044	+5.614	.003	.003	1	7
STOMACH	ASTN2 →	+4.807	+4.807	.008	.008	1	4
STOMACH	DSP →	+4.807	+4.807	.008	.008	1	4
BLOOD_Lymphoma	NEFH →	+4.429	+5.247	.005	.005	1	4
BONE	HIVEP3 →	+5.437	+5.437	.003	.003	1	4
LUNG_NSCLC_LUAD	STARD9 →	+2.830	+4.469	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,259 associations by consensus.

CNTN4 by CDKL5 expression — CNS

Explore this box plot interactively →