CDKL4

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CDKL4 mutation is significantly associated with the RNA expression of many other genes, with 646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKL4-associated genes across cancer lineages are RNA5SP411, RNU6-1318P, and RPL32P28. Each is linked with CDKL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKL4-to-partner and partner-to-CDKL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL4→partner) and Y-score (partner→CDKL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNA5SP411 →+0.987+2.683<.001<.00132
BRCARNU6-1318P →+0.599+4.209.004.00932
UCECRPL32P28 →+0.247+1.703<.001.00832
UCECVTRNA2-2P →+0.303+1.895.005.00732
UCECRNA5SP410 →+0.777+2.789<.001<.00132
UCECRNA5SP413 →+0.909+1.987<.001.00232
Each partner links to its Q-omics profile. Showing the 6 strongest of 646 associations by consensus.

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