Across TCGA cell cohorts, CDKL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 932 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CDKL4-associated GO terms across cancer lineages are Negative regulation of hematopoietic stem cell differentiation, Alternative mRNA splicing, via spliceosome, and Regulation of stem cell differentiation. Each is linked with CDKL4 in more than 6 cancer types. Because this analysis shows association rather than direction, both CDKL4-to-partner and partner-to-CDKL4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL4→partner) and Y-score (partner→CDKL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of hematopoietic stem cell differentiation →	+0.110	+0.129	.002	.009	2	7
OVARY	Alternative mRNA splicing, via spliceosome →	+0.072	+0.138	.001	.004	3	6
OVARY	Regulation of stem cell differentiation →	+0.078	+0.162	<.001	<.001	3	5
LIVER	Positive regulation of TORC1 signaling →	+0.046	+0.072	.004	.007	3	5
SOFT_TISSUE	Negative regulation of purine nucleotide metabolic process →	+0.119	+0.111	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	Heterochromatin formation →	+0.060	+0.074	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 932 associations by consensus.

Exploration

CDKL4 survival (RNA) · tumor vs normal (RNA) · all CDKL4 data types