Across TCGA cell cohorts, CDKL4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDKL4-associated genes across cancer lineages are OR10AG1, C10orf120, and GHRH. Each is linked with CDKL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKL4-to-partner and partner-to-CDKL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL4→partner) and Y-score (partner→CDKL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10AG1 →	+0.013	+5.169	<.001	.005	3	1
BREAST	C10orf120 →	+0.023	+5.169	<.001	.005	3	1
OVARY	GHRH →	+0.296	+5.196	<.001	.005	3	1
OVARY	MLN →	+0.890	+5.807	<.001	.001	3	1
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.027	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

CDKL4 survival (RNA) · tumor vs normal (RNA) · all CDKL4 data types