CDKL3

Across TCGA patient cohorts, CDKL3 protein abundance is significantly associated with the RNA expression of many other genes, with 7,337 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CDKL3-associated genes across cancer lineages are TGFB3, CNRIP1, and APBB2. Each is linked with CDKL3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDKL3-to-partner and partner-to-CDKL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDKL3 versus TGFB3 in BRCA, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL3→partner) and Y-score (partner→CDKL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TGFB3 →	+0.968	+0.371	.002	.002	3	5
UCEC	CNRIP1 →	+1.143	+0.423	<.001	.002	3	5
BRCA	APBB2 →	+1.153	+0.478	<.001	.001	3	5
BRCA	MSRB3 →	+0.890	+0.303	<.001	.004	3	5
OV	CALHM5 →	+0.722	+0.646	.002	<.001	3	5
UCEC	PRKG1 →	+0.979	+0.440	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,337 associations by consensus.

CDKL3 vs TGFB3 — BRCA

Explore this scatter interactively →