CDKL3

Across TCGA patient cohorts, CDKL3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKL3-associated genes across cancer lineages are STAT3_pY705, ATM, and 14-3-3_beta. Each is linked with CDKL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKL3-to-partner and partner-to-CDKL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CDKL3-low versus CDKL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL3→partner) and Y-score (partner→CDKL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.424	-3.087	<.001	<.001	3	2
UCEC	ATM →	-0.599	-3.807	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.088	-1.673	.011	.040	3	1
UCEC	EGFR_pY1068 →	-0.284	-3.700	.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.149	-3.000	<.001	<.001	3	1
UCEC	FoxM1 →	+0.241	+1.736	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

STAT3_pY705 by CDKL3 expression — UCEC

Explore this box plot interactively →