CDKL3

Across TCGA cell cohorts, CDKL3 mutation is significantly associated with the drug of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDKL3-associated genes across cancer lineages are SGC-CBP30, GSK2110183B, and Picolinici-acid. Each is linked with CDKL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKL3-to-partner and partner-to-CDKL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGC-CBP30 grouped by CDKL3-low versus CDKL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL3→partner) and Y-score (partner→CDKL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGC-CBP30 →	+0.322	+2.649	.022	.046	2	1
LARGE_INTESTINE	GSK2110183B →	+0.606	+2.649	.047	.046	2	1
LARGE_INTESTINE	Picolinici-acid →	+0.311	+2.646	.033	.047	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SGC-CBP30 by CDKL3 expression — LARGE_INTESTINE

Explore this box plot interactively →