CDKL2

Across TCGA patient cohorts, CDKL2 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,619 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDKL2-associated proteins across cancer lineages are JUP, DDAH1, and DPYSL2. Each is linked with CDKL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDKL2-to-partner and partner-to-CDKL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDKL2 versus JUP in LSCC, with a Pearson correlation of -0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL2→partner) and Y-score (partner→CDKL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	JUP →	-0.644	-0.665	<.001	<.001	3	5
LUAD	DDAH1 →	+0.531	+1.235	<.001	<.001	3	5
GBM	DPYSL2 →	+0.415	+0.977	<.001	<.001	3	5
LUAD	NUCKS1_S214 →	+0.390	+1.386	<.001	<.001	3	4
LUAD	SYNE1 →	+0.394	+1.726	<.001	<.001	3	4
GBM	TMEM30A →	+0.446	+0.983	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,619 associations by consensus.

CDKL2 vs JUP — LSCC

Explore this scatter interactively →