CDKL2

Across TCGA patient cohorts, CDKL2 protein abundance is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. OV shows the largest number of these associations.

The most reproducible CDKL2-associated genes across cancer lineages are CYP3A5, DHX15, and CLIC5. Each is linked with CDKL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKL2-to-partner and partner-to-CDKL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDKL2 versus CYP3A5 in OV, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL2→partner) and Y-score (partner→CDKL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYP3A5 →	+0.915	+0.778	<.001	.006	3	1
OV	DHX15 →	+0.977	+0.778	.006	.006	3	1
OV	CLIC5 →	-2.954	-1.025	.007	.004	3	1
OV	LYVE1 →	+2.065	+1.000	.005	.006	3	1
OV	ACRV1 →	-1.049	-1.025	.003	.004	3	1
OV	FHDC1 →	-1.795	-1.025	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

CDKL2 vs CYP3A5 — OV

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